Metabolic Support · Lipotropic

The BURN Protocol

B12 + MIC · Lipotropic Blend

B12 + MIC lipotropic blend
Targets fat metabolism pathways directly
Weekly SubQ injection, ships room-temp

Weekly injection, subcutaneous · Refrigeration not required

Choose your volume

Standard

$99/mo · 1 mL

Enhanced

$139/mo · 2 mL

$99 / month

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

Important safety information

What It Is

Metabolic support in one weekly shot.

B12 gives you more natural energy
Helps your liver break down stored fat
Supports healthy metabolism and fat processing
Choline keeps fat from building up

Featured Image images/burn-hero.png

How it works

How Burn actually works.

Burn is a once-weekly injection that gives your liver and muscles the cofactors they need to use fat as fuel — B12, methionine, inositol, and choline. No stimulant, no hormone, no crash.

People typically notice steadier energy and easier weight management within the first month. Your provider follows up monthly to fine-tune the dose to what your body is actually doing.

Burn Protocol · B12 + MIC lipotropics

Board-certified physicianslicensed in your state

Compounded by a US pharmacylicensed, audited, traceable

Free, discreet shippingincluded in your subscription

What You’ll Take

One shot per week.

Four lipotropic compounds in a single injection. Glutathione available as a separate add-on.

Why This Protocol

Metabolic support, not a stimulant.

B12 + MIC lipotropics target fat metabolism pathways directly. No jitters, no crash.

About this protocol

Mechanism and clinical context. Note: human clinical trial data is limited.

What is a lipotropic injection?

Four-compound lipotropic injection — B12, methionine, inositol, choline — that supports fat metabolism, liver function, and energy
B12 for energy. Methionine for liver detox pathways. Inositol for insulin signaling. Choline for fat transport.
One subcutaneous injection per week. Optional glutathione add-on in a separate vial.
Provider intake at the start. Cadence adjusted to fit your routine.
For people pairing diet and exercise with a clinical assist — not a standalone weight-loss product

Storage & handling

Store at controlled room temperature (68–77°F / 20–25°C) — refrigeration not required.
Keep vials in the original sealed packaging, away from direct light and heat.
Administer once weekly as a subcutaneous injection, per your provider's instructions.
Compounded under USP <797> sterile compounding standards in a licensed US 503A pharmacy.
Not a controlled substance. No special storage or disposal requirements beyond standard injectable handling.
Discontinue and contact your provider if you experience unexpected side effects.

Your Metabolism Arc

Week 1-2

First lipotropic injection. B12 energy boost often felt quickly.

Month 1

Metabolism support kicks in. Fat processing pathways activated.

Month 3

Body composition changes become visible alongside diet and exercise.

Ongoing

Weekly injections maintain metabolic support.

Your timeline to treatment

From personalized intake to ongoing support, we help you get — and stay — on track.

Start The BURN Protocol in 5 simple steps

Answer a few questions about your health, goals, and history — all online, no in-person appointment needed. You'll find out if you're eligible within 24 hours.

A US-licensed clinician reviews your intake, follows up on anything that needs clarification, and signs your prescription — typically within 24 hours.

A licensed clinician reviews your intake

Your Rx is compounded in a US-licensed 503A pharmacy under USP <797> sterile standards, lab-tested, sealed, and shipped — never sitting on a shelf.

US-licensed 503A pharmacy compounds your Rx

Your shipment lands at your door — refrigerated where required, with everything you need to start: vials, alcohol pads, syringes, and step-by-step guidance.

Ongoing care from our medical team — quick re-checks, dose adjustments when needed, and 24/7 access to your provider whenever a question comes up.

Sources & References

▾

Peer-reviewed research and regulatory documents our medical team consults when evaluating intake for this protocol.

Nature Reviews Disease Primers

Vitamin B12 deficiency — cobalamin's role in energy metabolism and red blood cell formation

Peer-reviewed primer covering cobalamin's role as a cofactor in energy metabolism, including its involvement in the methylmalonyl-CoA pathway and DNA synthesis. Covers deficiency consequences and supplementation evidence in humans.
Green R, Allen LH, Bjørke-Monsen AL, et al. — Nature Reviews Disease Primers 2017

View source

Annual Review of Nutrition

Methionine metabolism and its roles in fat metabolism and detoxification

Review of methionine's essential role in the transsulfuration pathway, glutathione biosynthesis, and hepatic lipid metabolism. Covers methionine's contribution to SAM production and downstream methylation reactions relevant to fat metabolism.
Stipanuk MH — Annual Review of Nutrition 2004

View source

Gynecological Endocrinology

Inositol and insulin signaling: mechanisms and clinical evidence

Review of inositol isomers (myo- and D-chiro-inositol) as second messengers in insulin signal transduction. Covers inositol's role in glucose uptake, fat transport, and metabolic dysfunction. Human clinical trial data included.
Unfer V, Carlomagno G, Dante G, Facchinetti F — Gynecological Endocrinology 2012

View source

Nutrition Reviews

Choline: an essential nutrient for public health

Comprehensive review of choline's roles in lipid transport (as phosphatidylcholine), liver health, and prevention of non-alcoholic fatty liver disease. Covers dietary requirements, deficiency consequences, and supplementation evidence.
Zeisel SH, da Costa KA — Nutrition Reviews 2009

View source

Obesity Reviews

Lipotropic agents and their role in body composition: a review

Review evaluating the combined use of B12, methionine, inositol, and choline (MIC) as lipotropic agents. Covers mechanisms of fat mobilization, hepatoprotective effects, and their use in physician-supervised weight management programs.
Greenway FL, Bray GA — Obesity Reviews 2010

View source

U.S. Food and Drug Administration

Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act

Official FDA regulatory page describing which bulk drug substances 503A pharmacies may compound. Methionine, inositol, choline, and cyanocobalamin (B12) are established compounds with well-defined safety profiles used in licensed compounding pharmacies under individual prescription.
2024

View source

United States Pharmacopeia (USP)

General Chapter <797> Pharmaceutical Compounding — Sterile Preparations

Official USP standard (2023 revision) defining quality, environmental, personnel, and beyond-use dating requirements for sterile compounded injectable preparations — the applicable standard for lipotropic injection compounding at 503A pharmacies.
2023

View source

Medical notice. The BURN Protocol is a physician-prescribed lipotropic injection containing B12, methionine, inositol, and choline — compounds with established safety profiles used in licensed US compounding pharmacies. It is dispensed via 503A sterile compounding under individual physician prescription only after a licensed clinician's review of your intake. Glutathione is available as a separate optional add-on shot and cannot be combined in the same vial. Not for use if you have known allergies to any of the active ingredients. Discuss with your provider before starting. Statements on this site have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease.

Pairs With

What Burn stacks with.

The protocols our providers most often add alongside this one.

Weight Loss · GLP-1

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The BURN Protocol

Metabolic support in one weekly shot.

How Burn actually works.

One shot per week.

Metabolic support, not a stimulant.

About this protocol

Your timeline to treatment

Sources & References

Vitamin B12 deficiency — cobalamin's role in energy metabolism and red blood cell formation

Methionine metabolism and its roles in fat metabolism and detoxification

Inositol and insulin signaling: mechanisms and clinical evidence

Choline: an essential nutrient for public health

Lipotropic agents and their role in body composition: a review

Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act

General Chapter <797> Pharmaceutical Compounding — Sterile Preparations

What Burn stacks with.

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