Your metabolism.
Back on your side.

Lipotropic Injection (B12 + MIC)

Designed to support faster fat metabolism and steadier all-day energy — two quick shots a week, one shipment a quarter.

Find my match

A woman in a terracotta knit holding a navy Nuvari shipping box to her chest — one delivery for the whole quarter

One shot.Ninety days.

One box covers the whole quarter — twice-weekly doses, nothing to reorder.

A man in a terracotta tee laughing toward someone off-frame on the BURN Protocol

Support for how you burn fuelMIC + B12, TWICE A WEEK AT HOME

An athletic woman jogging lightly in place in warm studio light

Metabolic support.Twice a week.

Helps your body turn fat into fuel — and keeps energy steady.

Metabolism, Meet Momentum.

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

3, 6, and 12-month plans at checkout — save up to 20% · Cancel anytime

Compounded medications are not FDA-approved. Product imagery is illustrative only — the bottles, capsules and tablets shown are renderings, not the exact container you will receive. Medications are compounded and dispensed by a licensed U.S. partner pharmacy, and actual packaging, labeling and dosage form appearance will differ.

RXMen & women

MIC + B12 Injection

Lipotropic Twice weekly · self-injection $86/mo2-month plan · from $71 MIC + B12 Injection

Lipotropic Get started Important Safety Information

Metabolism is a long game.

How MIC + B12 works in the body

Start the BURN

Supports
fat metabolism

Two hands holding The Burn Protocol MIC + B12 injection vial, fingers curled around the glass, on a peach studio backdrop

Methionine, inositol, and choline are lipotropics — compounds studied for how the body breaks down and transports fat.¹

Supports
cellular energy

A man kneeling to lace his running shoe, looking up with an energised grin on a peach studio backdrop

B12 supports red blood cell production and normal energy metabolism — turning food into usable energy.¹

Supports
liver function

The liver is where fat gets processed — MIC cofactors support its role in lipid metabolism.¹

The routine

Two quick shots a week — one shipment a quarter

Support without the GLP-1 tradeFour lipotropic cofactors plus B12 — support for fat metabolism and steady energy, without the GLP-1 side-effect profile.¹

Guardrails by designPrescription only. A licensed provider reviews your intake and every refill.

From $71/mo on a planStart it, stop it, or switch lanes with your provider at any point.

¹ Findings from research on the individual ingredients — vitamin B12, methionine, inositol, and choline — in specific populations, alongside diet and exercise. Nuvari prescribes a compounded MIC + B12 lipotropic blend dispensed by a licensed US pharmacy. Compounded medications are not FDA-approved. Individual results vary. See Sources & References.

Why MIC + B12

MIC + B12 Benefits

May support steadier all-day energy¹
Supports the way your body processes fat¹
Gentle on the stomach — no GLP-1 side-effect profile
Two quick shots a week — one quarterly shipment
Works best alongside a healthy diet and regular movement

¹ Structure-and-function statements about the MIC + B12 cofactor blend — see Sources & References. These statements have not been evaluated by the FDA. Individual results vary.

Board-certified physicianslicensed in your state

Compounded by a US pharmacylicensed, audited, traceable

Free, discreet shippingincluded in your subscription

What You’ll Take

One shot, one goal.

MIC + B12 — four lipotropic compounds, twice a week, shipped one quarter at a time, with glutathione available as a separate add-on.

Why This Protocol

Support without the side-effect trade.

MIC + B12 supports fat-processing pathways without the GLP-1 side-effect profile. No jitters in the shot, no crash — and a quarterly cadence that stays out of your way.

About this protocol

Mechanism and clinical context. Note: human clinical trial data is limited.

The medication

MIC + B12 Injectionthe quarterly lipotropic shot — twice a week, at home
Glutathione add-onoptional separate shot, never combined in the same vial

Inside the formula

Methionine, Inositol & Cholinelipotropic cofactors studied for how the body processes fat
Vitamin B12supports red blood cell production and normal energy metabolism

Ships cold-packed once a quarter with all supplies. Physician-prescribed and dispensed by a licensed US pharmacy.

Your Metabolism Arc

Week 1-2

First twice-weekly injections. B12 energy support is often felt early.

Month 1

The routine settles in — two quick injections a week, at home.

Month 3

Your first quarter complete. Changes build alongside diet and exercise.

Ongoing

One shipment a quarter keeps the protocol going without the monthly errand.

Your timeline to treatment

From personalized intake to ongoing support, we help you get — and stay — on track.

Start The BURN Protocol in 5 simple steps

Answer a few questions about your health, goals, and history — all online, no in-person appointment needed.

A US-licensed clinician reviews your intake, follows up on anything that needs clarification, and signs your prescription.

A licensed clinician reviews your intake

Your Rx is compounded in a US-licensed 503A pharmacy under USP <797> sterile standards, lab-tested, sealed, and shipped — never sitting on a shelf.

US-licensed 503A pharmacy compounds your Rx

Your shipment lands at your door — refrigerated where required, with everything you need to start: vials, alcohol pads, syringes, and step-by-step guidance.

Ongoing care from our medical team — message your provider any time, with quick reviews and dose adjustments when needed.

Sources & References

▾

Peer-reviewed research and regulatory documents our medical team consults when evaluating intake for this protocol.

Nature Reviews Disease Primers

Vitamin B12 deficiency — cobalamin's role in energy metabolism and red blood cell formation

Peer-reviewed primer covering cobalamin's role as a cofactor in energy metabolism, including its involvement in the methylmalonyl-CoA pathway and DNA synthesis. Covers deficiency consequences and supplementation evidence in humans.
Green R, Allen LH, Bjørke-Monsen AL, et al. — Nature Reviews Disease Primers 2017

View source

Annual Review of Nutrition

Methionine metabolism and its roles in fat metabolism and detoxification

Review of methionine's essential role in the transsulfuration pathway, glutathione biosynthesis, and hepatic lipid metabolism. Covers methionine's contribution to SAM production and downstream methylation reactions relevant to fat metabolism.
Stipanuk MH — Annual Review of Nutrition 2004

View source

Gynecological Endocrinology

Inositol and insulin signaling: mechanisms and clinical evidence

Review of inositol isomers (myo- and D-chiro-inositol) as second messengers in insulin signal transduction. Covers inositol's role in glucose uptake, fat transport, and metabolic dysfunction. Human clinical trial data included.
Unfer V, Carlomagno G, Dante G, Facchinetti F — Gynecological Endocrinology 2012

View source

Nutrition Reviews

Choline: an essential nutrient for public health

Comprehensive review of choline's roles in lipid transport (as phosphatidylcholine), liver health, and prevention of non-alcoholic fatty liver disease. Covers dietary requirements, deficiency consequences, and supplementation evidence.
Zeisel SH, da Costa KA — Nutrition Reviews 2009

View source

Current Opinion in Gastroenterology

Choline metabolism provides novel insights into non-alcoholic fatty liver disease and its progression

Review of choline metabolism and the export of fat from the liver, the mechanism behind the lipotropic role of choline and methionine.
Corbin KD, Zeisel SH — Current Opinion in Gastroenterology 2012;28(2):159-165

View source

U.S. Food and Drug Administration

Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act

Official FDA regulatory page describing which bulk drug substances 503A pharmacies may compound. Methionine, inositol, choline, and cyanocobalamin (B12) are established compounds with well-defined safety profiles used in licensed compounding pharmacies under individual prescription.
2024

View source

United States Pharmacopeia (USP)

General Chapter <797> Pharmaceutical Compounding — Sterile Preparations

Official USP standard (2023 revision) defining quality, environmental, personnel, and beyond-use dating requirements for sterile compounded injectable preparations — the applicable standard for lipotropic injection compounding at 503A pharmacies.
2023

View source

Medical notice. The BURN Protocol is a physician-prescribed lipotropic injection containing B12, methionine, inositol, and choline — compounds with established safety profiles used in licensed US compounding pharmacies. It is dispensed via 503A sterile compounding under individual physician prescription only after a licensed clinician's review of your intake. Glutathione is available as a separate optional add-on shot and cannot be combined in the same vial. Not for use if you have known allergies to any of the active ingredients. Discuss with your provider before starting. Statements on this site have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease.

Pairs With

What Burn stacks with.

The protocols our providers most often add alongside this one.

Weight Loss · GLP-1

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Your metabolism.Back on your side.

Lipotropic Injection (B12 + MIC)

One shot.Ninety days.

Metabolic support.Twice a week.

Metabolism, Meet Momentum.

MIC + B12 Injection

Metabolism is a long game.

Supportsfat metabolism

Supportscellular energy

Supportsliver function

Two quick shots a week — one shipment a quarter

MIC + B12 Benefits

One shot, one goal.

Support without the side-effect trade.

About this protocol

The medication

Inside the formula

Your timeline to treatment

Sources & References

Vitamin B12 deficiency — cobalamin's role in energy metabolism and red blood cell formation

Methionine metabolism and its roles in fat metabolism and detoxification

Inositol and insulin signaling: mechanisms and clinical evidence

Choline: an essential nutrient for public health

Choline metabolism provides novel insights into non-alcoholic fatty liver disease and its progression

Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act

General Chapter <797> Pharmaceutical Compounding — Sterile Preparations

Related reading

How online weight-loss injections work and what they cost

Why weight-loss plateaus happen and what actually helps

Are compounded medications safe? How 503A pharmacies are regulated

What Burn stacks with.

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Your metabolism.
Back on your side.

Supports
fat metabolism

Supports
cellular energy

Supports
liver function