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All Protocols  ›  Weight Loss  ›  The SHED Protocol

Less weight.
More you.

GLP-1 Weight Loss: Semaglutide & Tirzepatide

Designed to quiet hunger and cravings so eating less feels natural — semaglutide or tirzepatide.

Find my match

Semaglutide.Chewed, not shot.

See the science
Tirzepatidesame molecule as the weekly shot Semaglutideabsorbed orally, no needle Chewable tablet breaking in half
Life on the SHED Protocol Weight loss, made simplerPHYSICIAN-DIRECTED

A quieter appetite.Progress you can keep.

SemaglutideTirzepatideChewableTablet

Shot, Tablet, Or Chew? Your Call.

Prescription only Free shipping Provider review in 24h US-licensed pharmacy
3, 6, and 12-month plans at checkout — save up to 20% · Cancel anytime
Compounded medications are not FDA-approved. Product imagery is illustrative only — the bottles, capsules and tablets shown are renderings, not the exact container you will receive. Medications are compounded and dispensed by a licensed U.S. partner pharmacy, and actual packaging, labeling and dosage form appearance will differ.
RXMen & women

Semaglutide Injection

Semaglutide Once weekly · the original $179/moplans from $169 Semaglutide InjectionSemaglutide Get started Important Safety Information
RXOUR STRONGESTMen & women

Tirzepatide Injection

Tirzepatide Once weekly · dual-action $279/moplans from $259 Tirzepatide InjectionTirzepatide Get started Important Safety Information
RXGENTLE RESTARTMen & women

Tirzepatide Chewable

Tirzepatide Daily chewable · no needle $229/moplans from $179 Tirzepatide ChewableTirzepatide Get started Important Safety Information
RXMen & women

Semaglutide ODT

Daily tablet · dissolves $169/moplans from $132 Semaglutide ODTSemaglutide Get started Important Safety Information

Needle or No Needle.
Your call.

SHED covers both — weekly injections or daily oral options, prescribed online and shipped free to your door.

Get started Which one fits me?

Your future self is watching.

Start the SHED

Based on trials of branded GLP-1 medicines — not this compounded product.

A heart that
keeps up¹

cardiovascular risk, in the research

Weight that
stays off¹

weight-loss maintenance, in the research

Energy without the
spike and crash¹

blood sugar, in the research

¹ Findings from trials of branded GLP-1 medicines in specific populations, alongside diet and exercise. Cited trials studied weekly subcutaneous injection; oral and chewable formats were not studied in these trials. Nuvari prescribes compounded formulations built on the same active ingredient classes. Compounded medications are not FDA-approved. Individual results vary.

Semaglutide or tirzepatide

One pathway, or two.

Both quiet appetite through the same GLP-1 pathway. Tirzepatide adds a second one, GIP. That is the difference in how they work — your provider decides which is appropriate for you.

Semaglutide

The established original
  • Acts on the GLP-1 pathway
  • Weekly injection or a daily dissolving tablet
  • The lower-priced of the two lanes

From $132/mo

Tirzepatide

Dual pathway
  • Acts on GLP-1 and GIP
  • Weekly injection or a daily chew
  • Our strongest lane

From $179/mo

Start your visit →

Prescription only, if appropriate. Compounded medications are not FDA-approved and are not the branded products studied in clinical trials. Wegovy® and Zepbound® are registered trademarks of their respective owners; Nuvari is not affiliated with or endorsed by them. Important Safety Information: semaglutide · tirzepatide

Board-certified physicianslicensed in your state
Dispensed by a licensed US pharmacylicensed, audited, traceable
Free, discreet shippingincluded in your subscription
What You’ll Take

Needle-free or weekly injection.

Semaglutide or tirzepatide — a needle-free oral dose or a weekly injection, shipped from a licensed pharmacy.

Why This Protocol

Both molecules. One flat price. Every dose.

Semaglutide or tirzepatide, compounded and dispensed by a licensed US pharmacy, prescribed by a US-licensed physician — and your price never changes as your provider adjusts your dose.

Medical notice. The SHED Protocol uses compounded GLP-1 medications (semaglutide or tirzepatide) prescribed only after clinical evaluation by a US-licensed clinician. Compounded medications are not FDA-approved or FDA-evaluated. Common side effects include nausea, vomiting, diarrhea, and constipation. Not appropriate for patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2; tell your provider promptly about any neck lump, hoarseness, or trouble swallowing. Risk of pancreatitis, gallbladder disease, and hypoglycemia when used with insulin. Discuss the risks and benefits with your provider.

About this protocol

Technical and clinical context our providers use when evaluating intake.

The medications

  • Semaglutide Injectionthe original weekly GLP-1
  • Tirzepatide Injectiondual-action weekly, our strongest
  • Tirzepatide Chewabledaily, needle-free, half-tab restarts
  • Semaglutide ODTdaily dissolving tablet

Inside the formulas

  • SemaglutideGLP-1 receptor agonist — quiets hunger and cravings
  • TirzepatideGLP-1 + GIP dual agonist — two hunger pathways
  • Glycine & B12co-formulated support in the injectable blends

Injectables ship cold-packed and refrigerate at 36–46°F; oral formats ship and store at room temperature. Physician-prescribed and dispensed by a licensed US pharmacy.

Your Weight Loss Arc

Week 1

First dose — started gently, whether it's your first attempt or a restart. Baseline weight logged.

Month 1

Dose increases gradually. Some begin to see early progress.

Month 3

Steady-state dosing, with ongoing provider oversight.

Month 6+

Maintenance phase. Your provider helps you sustain your progress.

Your timeline to treatment

From personalized intake to ongoing support, we help you get — and stay — on track.

Start The SHED Protocol in 5 simple steps

Answer a few questions about your health, goals, and history — all online, no in-person appointment needed.

Take your online intake on your phone

A US-licensed clinician reviews your intake, follows up on anything that needs clarification, and signs your prescription.

A licensed clinician reviews your intake

Your Rx is filled at a licensed US pharmacy and shipped directly to your door — needle-free oral doses at room temperature, injectables cold-packed and sealed.

Licensed pharmacy dispenses your prescription

Your shipment lands at your door — refrigerated where required, with everything you need to start and clear step-by-step guidance (injectable doses include alcohol pads and syringes).

Your shipment arrives at your door

Ongoing care from our medical team — message your provider any time, with quick reviews and dose adjustments when needed.

Ongoing care from your provider

Peer-reviewed research and regulatory documents our medical team consults when reviewing intake for GLP-1 protocols. Note: these trials studied branded, weekly subcutaneous formulations — not this compounded product or its oral formats.

FDA / DailyMed

Wegovy® (semaglutide) — Full Prescribing Information

FDA-approved label for branded semaglutide for weight management. Auto-updates from NIH DailyMed.
Novo Nordisk · revised March 2026

View source

FDA / DailyMed

Semaglutide — Full Prescribing Information

FDA-approved label for branded semaglutide for type 2 diabetes and cardiovascular/renal risk reduction.
Novo Nordisk · revised October 2025

View source

NEJM

STEP 1 — Once-weekly semaglutide in adults with overweight or obesity

Pivotal phase 3 trial (n=1961): 14.9% mean weight loss with semaglutide 2.4 mg vs 2.4% placebo at 68 weeks.
Wilding JPH, et al. — NEJM 2021

View source

JAMA

STEP 4 — Continued semaglutide vs placebo on weight-loss maintenance

Randomized withdrawal trial showing continued therapy maintains weight loss; switching to placebo causes regain.
Rubino D, et al. — JAMA 2021

View source

JAMA

STEP 8 — Weekly semaglutide vs daily liraglutide for weight loss

Head-to-head trial (n=338): semaglutide 2.4 mg −15.8% vs liraglutide 3.0 mg −6.4% at 68 weeks.
Rubino DM, et al. — JAMA 2022

View source

Lancet Diabetes & Endocrinology

SUSTAIN 1 — Once-weekly semaglutide monotherapy in type 2 diabetes

First pivotal phase 3a trial of subcutaneous semaglutide in treatment-naïve T2DM; HbA1c and weight reduction at 30 weeks.
Sorli C, et al. — Lancet Diabetes & Endocrinology 2017

View source

FDA / DailyMed

Tirzepatide — Full Prescribing Information

FDA-approved label for tirzepatide (GIP/GLP-1 receptor agonist) for chronic weight management.
Eli Lilly · revised 2024

View source

ClinicalTrials.gov

STEP 1 — Trial registry record (NCT03548935)

Official trial registry: protocol, endpoints, sponsor (Novo Nordisk), and result-reporting tied to the NEJM 2021 publication.

View source

Wegovy® and Zepbound® are registered trademarks of their respective owners. Nuvari is not affiliated with or endorsed by them.

Related reading

Background from the Nuvari journal on the medications in this protocol.

Cost

What compounded tirzepatide costs in 2026, and why
Compare

Tirzepatide vs semaglutide: how the two GLP-1s differ
Getting started

Your first week on semaglutide: what to expect
Pairs With

What Shed stacks with.

The protocols our providers most often add alongside this one.

Metabolic Support · Lipotropic

Burn

Burn smarter, not harder.
→
Peptide Therapy · Anti-Aging

Rewind

Support your body's natural renewal.
→
Cellular Energy · NAD+

Ignite

Relight your cells. Reclaim your energy.
→
Begin the SHED →