Weight Loss · GLP-1

The SHED Protocol

Semaglutide or tirzepatide — GLP-1 without the needle
Dissolves in your mouth — no injections
Room-temperature, discreet shipping

Daily or weekly oral dose · Room-temperature shipment

Start intake

From $229/month · cancel anytime

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

Important safety information: semaglutide · tirzepatide

Semaglutide or tirzepatide — weekly GLP-1 injection
One weekly dose · helps you feel full longer
Cold-packed from a licensed pharmacy

Weekly injection, subcutaneous · Refrigerate after receipt

Start intake

From $249/month · cancel anytime

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

Important safety information: semaglutide · tirzepatide

What It Is

GLP-1 weight loss — needle-free or injectable, prescribed for you.

Reduces hunger and cravings naturally
Helps you feel full longer after eating
Supports your body's blood-sugar response
Provider-guided dosing, adjusted to you

Compare Your Options

Semaglutide

GLP-1 Agonist

Best for

The well-established option for steady, sustained weight loss

What's good

Targets appetite and cravings naturally
Slows digestion so you stay full longer
Gradual 5-step dose titration
Pause and resume anytime

PriceFrom $229/mo

Onset4-8 weeks

FreqDaily or weekly

FormatOral or injection

Needle-free from $229/mo

Tirzepatide

Dual GLP-1/GIP

Best for

Dual-action for those seeking enhanced metabolic response

What's good

Activates two receptors instead of one
May support stronger appetite control
Same weekly convenience
Emerging option for those who want more

PriceFrom $249/mo

Onset4-8 weeks

FreqDaily or weekly

FormatOral or injection

Needle-free from $249/mo

Featured Image images/shed-portrait.png

How it works

How Shed actually works.

Shed uses GLP-1 medications — semaglutide or tirzepatide — to help regulate appetite, slow gastric emptying, and support metabolic signaling. Your provider reviews your history and the clinical evidence for these medications when evaluating your intake.

Many patients see steady, sustainable progress over the first few months — individual results vary. Your provider follows you closely with monthly check-ins to titrate the dose and track progress in real terms, not just on a scale.

Shed Protocol · Semaglutide or Tirzepatide

Board-certified physicianslicensed in your state

Dispensed by a licensed US pharmacylicensed, audited, traceable

Free, discreet shippingincluded in your subscription

What You’ll Take

Needle-free or weekly injection.

Semaglutide or tirzepatide — a needle-free oral dose or a weekly injection, shipped from a licensed pharmacy.

Why This Protocol

Compounded GLP-1, prescribed for you.

Semaglutide or tirzepatide, compounded and dispensed by a licensed US pharmacy, prescribed by a US-licensed physician.

About this protocol

Technical and clinical context our providers use when evaluating intake.

What are GLP-1 medications?

GLP-1 receptor agonist — mimics a natural hormone that controls appetite, insulin response, and how fast your stomach empties
Semaglutide or tirzepatide (dual GIP/GLP-1) — your provider matches the right one to your situation
Available needle-free (oral dose) or as a weekly self-injection
Compounded and dispensed by a licensed US pharmacy. Provider follow-up at 4 and 12 weeks.
For people who want a clinically-managed metabolic approach with ongoing provider oversight

Storage & handling

Refrigerate at 36–46°F (2–8°C) before first use.
After first use, store as directed on your pharmacy label and use within the beyond-use date provided.
Do not freeze — discard if frozen.
Keep pen away from direct heat and sunlight.
Each pen comes with disposable needles.
Needle-free oral doses ship and store at room temperature.
Compounded and dispensed by a licensed US pharmacy.

Your Weight Loss Arc

Week 1

First dose. Baseline weight logged. Appetite changes may begin.

Month 1

Dose increases gradually. Some begin to see early progress — individual results vary.

Month 3

Steady-state dosing, with ongoing provider check-ins. Individual results vary.

Month 6+

Maintenance phase. Your provider helps you sustain your progress.

Your timeline to treatment

From personalized intake to ongoing support, we help you get — and stay — on track.

Start The SHED Protocol in 5 simple steps

Answer a few questions about your health, goals, and history — all online, no in-person appointment needed. You'll find out if you're eligible within 24 hours.

A US-licensed clinician reviews your intake, follows up on anything that needs clarification, and signs your prescription — typically within 24 hours.

A licensed clinician reviews your intake

Your Rx is filled at a licensed US pharmacy and shipped directly to your door — needle-free oral doses at room temperature, injectables cold-packed and sealed.

Licensed pharmacy dispenses your prescription

Your shipment lands at your door — refrigerated where required, with everything you need to start and clear step-by-step guidance (injectable doses include alcohol pads and syringes).

Ongoing care from our medical team — quick re-checks, dose adjustments when needed, and 24/7 access to your provider whenever a question comes up.

Sources & References

▾

Peer-reviewed research and regulatory documents our medical team consults when reviewing intake for GLP-1 protocols.

FDA / DailyMed

Wegovy (semaglutide) — Full Prescribing Information

FDA-approved label for branded semaglutide for weight management. Auto-updates from NIH DailyMed.
Novo Nordisk · revised March 2026

View source

FDA / DailyMed

Semaglutide — Full Prescribing Information

FDA-approved label for branded semaglutide for type 2 diabetes and cardiovascular/renal risk reduction.
Novo Nordisk · revised October 2025

View source

NEJM

STEP 1 — Once-weekly semaglutide in adults with overweight or obesity

Pivotal phase 3 trial (n=1961): 14.9% mean weight loss with semaglutide 2.4 mg vs 2.4% placebo at 68 weeks.
Wilding JPH, et al. — NEJM 2021

View source

JAMA

STEP 4 — Continued semaglutide vs placebo on weight-loss maintenance

Randomized withdrawal trial showing continued therapy maintains weight loss; switching to placebo causes regain.
Rubino D, et al. — JAMA 2021

View source

JAMA

STEP 8 — Weekly semaglutide vs daily liraglutide for weight loss

Head-to-head trial (n=338): semaglutide 2.4 mg −15.8% vs liraglutide 3.0 mg −6.4% at 68 weeks.
Rubino DM, et al. — JAMA 2022

View source

Lancet Diabetes & Endocrinology

SUSTAIN 1 — Once-weekly semaglutide monotherapy in type 2 diabetes

First pivotal phase 3a trial of subcutaneous semaglutide in treatment-naïve T2DM; HbA1c and weight reduction at 30 weeks.
Sorli C, et al. — Lancet Diabetes & Endocrinology 2017

View source

FDA / DailyMed

Tirzepatide — Full Prescribing Information

FDA-approved label for tirzepatide (GIP/GLP-1 receptor agonist) for chronic weight management.
Eli Lilly · revised 2024

View source

ClinicalTrials.gov

STEP 1 — Trial registry record (NCT03548935)

Official trial registry: protocol, endpoints, sponsor (Novo Nordisk), and result-reporting tied to the NEJM 2021 publication.

View source

Medical notice. The SHED Protocol uses compounded GLP-1 medications (semaglutide or tirzepatide) prescribed only after clinical evaluation by a US-licensed clinician. Compounded medications are not FDA-approved or FDA-evaluated. Common side effects include nausea, vomiting, diarrhea, and constipation. Not appropriate for patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2; tell your provider promptly about any neck lump, hoarseness, or trouble swallowing. Risk of pancreatitis, gallbladder disease, and hypoglycemia when used with insulin. Discuss the risks and benefits with your provider.

Pairs With

What Shed stacks with.

The protocols our providers most often add alongside this one.

Metabolic Support · Lipotropic

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The SHED Protocol

GLP-1 weight loss — needle-free or injectable, prescribed for you.

Semaglutide

Tirzepatide

How Shed actually works.

Needle-free or weekly injection.

Compounded GLP-1, prescribed for you.

About this protocol

Your timeline to treatment

Sources & References

Wegovy (semaglutide) — Full Prescribing Information

Semaglutide — Full Prescribing Information

STEP 1 — Once-weekly semaglutide in adults with overweight or obesity

STEP 4 — Continued semaglutide vs placebo on weight-loss maintenance

STEP 8 — Weekly semaglutide vs daily liraglutide for weight loss

SUSTAIN 1 — Once-weekly semaglutide monotherapy in type 2 diabetes

Tirzepatide — Full Prescribing Information

STEP 1 — Trial registry record (NCT03548935)

What Shed stacks with.

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