Finally, a plan
that listens.

Low-Dose Naltrexone (LDN)

Told your labs look normal but you still don’t feel right? Low-dose naltrexone, titrated to you — one nightly tablet, started low and raised slowly.

Find my match

Recovery Support

LDN Flex-Dose

Low dose.Raised slowly.

How it helps

A woman in her forties waking rested and unhurried in soft morning light on a seamless olive backdrop

For days that ask a lot of youFATIGUE · PAIN · INFLAMMATION

A man in his forties holding a mug of coffee on a seamless olive backdrop, calm and unhurried

For pain and inflammationONE NIGHTLY TABLET, TITRATED TO YOU

One Tablet, Titrated To You.

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

3, 6, and 12-month plans at checkout — save up to 20% · Cancel anytime

Your first month is a titration month — 0.5 toward a 4.5 mg nightly maintenance dose — billed monthly while your provider dials it in. Once your dose settles, maintenance plans start from $62/mo.

Compounded medications are not FDA-approved.

RXMen & women

LDN Flex-Dose

Naltrexone Nightly tablet · titration built in For fatigue, pain and inflammation that never got a name — started low, raised slowly. $69/moplans from $62 LDN Flex-Dose

Naltrexone Get started Important Safety Information

A smaller dose, doing a different job.

Made for the symptoms that never got a name.

Prescribed off-label for persistent fatigue¹
Prescribed off-label for ongoing pain¹
Studied for its signalling in inflammation¹
Non-sedating — not a controlled substance

Start the RECLAIM

¹ Low-dose naltrexone is prescribed off-label; as a compounded medication it is not FDA-approved, and this page describes what it is rather than making any claim to treat or cure any condition. Individual responses vary. Important Safety Information

Built into the tablet

Doses that rise as
your body adjusts.

Most prescriptions start where they end. RECLAIM starts at 0.5 mg and climbs gently across your first month — your provider sets each step, your first month bills monthly while the dose settles, and maintenance begins when your body says so.

Provider-set steps, not a fixed template
Maintenance at 4.5 mg nightly, plans from $62

Week 1

Start low

0.5 mg nightly — small on purpose, so your body has time to settle.

How you feelUsually no different yet. Starting this low is what keeps it that way.

Weeks 2–4

Step up

Your provider raises the dose only when you’re ready, toward 4.5 mg.

How you feelVivid dreams and lighter sleep are the most commonly reported early effects.

Weeks 4–8

Settle in

The dose holds while your provider reviews how you’re actually doing.

How you feelThose early effects often ease. Anything people notice tends to arrive gradually.

Month 3

Steady state

Maintenance at the dose that suits you, reviewed at every refill.

How you feelSettled into a nightly routine. Individual responses vary.

Board-certified physicianslicensed in your state

Dispensed by a licensed US pharmacylicensed, audited, traceable

Free, discreet shippingincluded in your subscription

What You’ll Take

One capsule each night.

Low-dose naltrexone — the same molecule as the standard 50 mg tablet, compounded to a fraction of that dose at your prescribed strength. Non-sedating, non-habit-forming, not a controlled substance.

Why This Protocol

The titration is the protocol.

Flex dosing from 0.5 to 4.5 mg means your first month is built for adjustment, not commitment — your provider steps the dose only when you're ready.

About this protocol

Technical and clinical context our providers use when evaluating intake for low-dose naltrexone therapy.

The medications

LDN Flex-Doselow-dose naltrexone with the titration month built in

Inside the formulas

Low-dose naltrexonean opioid-receptor modulator studied for its role in immune and nervous-system signaling

Tablets ship at room temperature. Opioid use is always screened before any prescription. Physician-prescribed and dispensed by a licensed US pharmacy.

Your Titration Arc

Week 1

Start at 0.5 mg nightly. The point of month one is adjustment, not judgment.

Month 1

Titration completes — your provider settles you at the dose that fits, up to 4.5 mg.

Month 2-3

You message your provider about how you actually feel; dose adjustments go through provider review. Individual responses vary.

Ongoing

Maintenance dosing on 3, 6, or 12-month plans from $62/mo — with a provider who keeps listening.

Your timeline to treatment

From personalized intake to ongoing support, we help you get — and stay — on track.

Start The RECLAIM Protocol in 5 simple steps

Answer a few questions about your health, goals, and history — all online, no in-person appointment needed. You'll find out if you're eligible within 24 hours.

A US-licensed clinician reviews your intake, follows up on anything that needs clarification, and signs your prescription — typically within 24 hours.

A licensed clinician reviews your intake

Your Rx is filled at a US-licensed 503A pharmacy, sealed, and shipped — room-temperature and ready to go from day one.

Your shipment arrives at your door — discreet, room-temperature, and ready to use. One capsule nightly, starting at the low end of your titration. No injections, no needles, no special storage.

Ongoing care from our medical team — message your provider any time, with quick reviews and dose adjustments when needed.

Sources & References

▾

Peer-reviewed research and regulatory documents our medical team consults when evaluating intake for this protocol.

FDA / DailyMed

ReVia® (naltrexone hydrochloride) Prescribing Information

Official label for standard-dose (50 mg) naltrexone hydrochloride — pharmacology, contraindications, and safety profile of the molecule. Low-dose naltrexone is compounded and prescribed off-label; this label covers the reference product.
DailyMed

View source

Medical Sciences

Low-Dose Naltrexone (LDN) — Review of Therapeutic Utilization

Peer-reviewed review of how low-dose naltrexone is used in clinical practice, its proposed mechanisms, and the current state of the evidence — which the authors note remains preliminary and based on small studies.
Toljan K, Vrooman B — Medical Sciences 2018

View source

Clinical Rheumatology

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory agent: a review

Review of the pharmacology proposed for naltrexone at low doses, including transient opioid-receptor modulation and glial-cell activity. Describes early-stage human research and calls for larger trials.
Younger J, Parkitny L, McLain D — Clinical Rheumatology 2014

View source

Pharmacotherapy

The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation

Peer-reviewed evaluation of low-dose naltrexone's safety profile and the published clinical data, noting that LDN is generally well tolerated and that the evidence base is still developing.
Patten DK, Schultz BG, Berlau DJ — Pharmacotherapy 2018

View source

ReVia® is a registered trademark of its owner. Nuvari is not affiliated with or endorsed by the trademark owner.

Medical notice. The RECLAIM Protocol is physician-prescribed low-dose naltrexone, compounded by a licensed US 503A pharmacy and dispensed only after clinical evaluation. Low-dose naltrexone is prescribed off-label; as a compounded medication it is not FDA-approved, and this page describes what it is rather than making any claim to treat or cure any condition. Naltrexone is contraindicated in patients currently using opioid medications, in acute opioid withdrawal, or with acute hepatitis or liver failure. Common side effects can include vivid dreams, sleep changes, headache, and nausea, often during titration. Naltrexone blocks opioid receptors — inform all healthcare providers and emergency personnel that you are taking this medication. Statements on this site have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual responses vary.

Pairs With

What Reclaim stacks with.

The protocols our providers most often add alongside this one.

Sleep · Recovery

Menu

Not sure where to start?

Join the waitlist

Ready to lose weight?

Start here

Tired, sluggish, not yourself?

Take the assessment

Restore your confidence

Get started

Invest in your future self

Find your protocol

Prescription hair regrowth

Start your protocol

Better rest starts here

Find what works

Finally, a planthat listens.

Low-Dose Naltrexone (LDN)

Low dose.Raised slowly.

One Tablet, Titrated To You.

LDN Flex-Dose

A smaller dose, doing a different job.

Made for the symptoms that never got a name.

Doses that rise asyour body adjusts.

Start low

Step up

Settle in

Steady state

One capsule each night.

The titration is the protocol.

About this protocol

The medications

Inside the formulas

Your timeline to treatment

Sources & References

ReVia® (naltrexone hydrochloride) Prescribing Information

Low-Dose Naltrexone (LDN) — Review of Therapeutic Utilization

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory agent: a review

The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation

Related reading

Low-dose naltrexone: what it is and how it works

Are compounded medications safe? How 503A pharmacies are regulated

Where off-label compounds sit in a longevity protocol

What Reclaim stacks with.

Drift

Apex

Rewind

Finally, a plan
that listens.

Doses that rise as
your body adjusts.