Menu

Not sure where to start?

Join the waitlist

 Explore All Protocols Nuvari+ Partner Program
Explore
Men's Health Women's Health
How It Works The Science Blog FAQs About Contact
Weight Loss

Ready to lose weight?

Start here
Explore
The Shed ProtocolSemaglutide & tirzepatide — shot, chew or dissolve. The Burn ProtocolMIC + B12 — twice-weekly injection. Weight Loss Overview BMI Calculator The Science — Shed The Science — Burn FAQs
Energy & Drive

Tired, sluggish, not yourself?

Take the assessment
Explore
The Apex ProtocolEnclomiphene — boost your own testosterone. Hormone Health Overview Hormone Assessment The Science
Sexual Wellness

Restore your confidence

Get started
Explore
The Desire ProtocolSildenafil, tadalafil & bremelanotide. Nuvari+ The Science FAQs
Anti-Aging & Longevity

Invest in your future self

Find your protocol
Explore
The Rewind ProtocolSermorelin & rapamycin — nightly. The Ignite ProtocolNAD+ — injection or sublingual. Peptides Overview The Science — Rewind The Science — Ignite
Hair & Skin

Prescription hair regrowth

Start your protocol
Explore
The Crown ProtocolFinasteride & minoxidil — tablet or topical. The Glow ProtocolTretinoin, hydroquinone & more — nightly. The Science — Crown The Science — Glow FAQs
Sleep & Recovery

Better rest starts here

Find what works
Explore
The Drift ProtocolRamelteon or trazodone — nightly. The Reclaim ProtocolLow-dose naltrexone — one nightly tablet. The Science — Drift The Science — Reclaim FAQs
All Protocols  ›  Skin  ›  The GLOW Protocol

Better skin.
One step.

Up to four prescription actives. One nightly cream.

Multiple prescription actives, compounded into one nightly cream — calibrated to your skin by a provider.

Find my match
Flagship formula Cu GlyHisLys

GHK-Cu, explained.The copper peptide inside Stella+.

  • Supports collagen
  • Helps skin repair
  • Calms redness
Stella+
Close-up of smooth, radiant skin around the eye — what Stella+ is built for
Fine lines
A woman with glowing skin in a cream knit top, hair up, gently resting a hand against her cheek For lines, dark spots & textureONE PRESCRIPTION CREAM, APPLIED NIGHTLY
A man and a woman at a bright bathroom mirror smoothing cream onto their cheeks in soft morning light

Better skin, on schedule.Prescribed online.

Prescription skincare, shipped to your door.

Six Formulas. One Nightly Step.

Prescription only Free shipping Provider review in 24h US-licensed pharmacy
2, 6, and 12-month plans at checkout — save up to 13% · Cancel anytime
Compounded medications are not FDA-approved. Product imagery is illustrative only — the bottles, capsules and tablets shown are renderings, not the exact container you will receive. Medications are compounded and dispensed by a licensed U.S. partner pharmacy, and actual packaging, labeling and dosage form appearance will differ.
Shop by:
RXHERO FORMULAWomen

Stella+

GHK-Cu + Estriol + Tretinoin + Niacinamide Pea-size · nightly For fine lines and firmness — peptide-and-retinoid renewal, nightly. $165/mo2-month plan · from $143 Fine lines & agingStella+GHK-Cu + Estriol + Tretinoin + Niacinamide Fine lines & aging → Important Safety Information
RXPCOS FORMULAWomen

Flawless

Azelaic acid + Metformin + Progesterone + Spironolactone Apply nightly For hormonal breakouts along the jaw and chin — calms and clears. $91/mo2-month plan · from $79 Hormonal breakoutsFlawlessAzelaic acid + Metformin + Progesterone + Spironolactone Hormonal breakouts → Important Safety Information
RXMen & women

Diamond Delux

Hydroquinone + Tretinoin + Triamcinolone Nightly · 12-week max cycles For dark spots and post-acne marks — fades uneven pigment. $63/mo2-month plan · from $55 Dark spotsDiamond DeluxHydroquinone + Tretinoin + Triamcinolone Dark spots → Important Safety Information
RXMen & women

Diamond Delux Plus

Hydroquinone + Kojic acid + Tretinoin + Triamcinolone Nightly · 12-week max cycles For stubborn pigment and melasma — the stronger brightening step. $63/mo2-month plan · from $55 Stubborn pigmentDiamond Delux PlusHydroquinone + Kojic acid + Tretinoin + Triamcinolone Stubborn pigment → Important Safety Information
RXMen & women

Tretinoin TAAN

Tretinoin + Azelaic acid + Niacinamide Pea-size · nightly For texture, congestion and dullness — smooths and resurfaces. $63/mo2-month plan · from $56 Texture & renewalTretinoin TAANTretinoin + Azelaic acid + Niacinamide Texture & renewal → Important Safety Information
RXMen & women

Luminance

Azelaic acid + Hydrocortisone + Hydroquinone + Kojic acid Nightly · 12-week max cycles For uneven tone and dullness — gentler all-over brightening. $63/mo2-month plan · from $56 Tone & brightnessLuminanceAzelaic acid + Hydrocortisone + Hydroquinone + Kojic acid Tone & brightness → Important Safety Information
Why Stella+

Why people choose
Stella+

Where each active works in the skin A cross-section of the cream on skin. The cream sits as a soft band on the surface. Beneath it, three softly shaded layers fade into depth. Niacinamide diffuses through the surface barrier layer, helping steady the skin barrier. GHK-Cu diffuses through the repair layer in copper, supporting repair signaling. Estriol sits in that same repair layer, for skin in hormonal transition. Tretinoin diffuses through the deepest renewing layer, helping renew from underneath. WHERE EACH ACTIVE WORKS Niacinamide helps steady the skin barrier GHK-Cu supports repair signaling Estriol for skin in hormonaltransition Tretinoin helps renew from underneath

Based on published studies of the individual ingredients — not clinical trials of this compounded product. Results vary.

Get started →
01

It works with your skin’s own biology.

Your skin already makes GHK-Cu to repair itself. We give it more — renewal without the burn of harsher actives.

Close-up of a woman smoothing a light cream into her cheek with two fingertips
02

Four actives, one calibrated cream.

Four actives most brands sell separately. One cream, one step, mixed to your provider’s spec.

Overhead close-up of a fingertip spreading a small dab of cream across the back of a hand
03

Hormone-aware by design.

Shelf creams ignore hormones. Estriol is here for skin that’s changing, not just aging.

Portrait of a woman in her late forties with calm, healthy skin, smiling softly off-camera

Skin your future self will thank you for.

Start the GLOW

Skin support, at
the cellular level.

Builds collagen and speeds skin renewalTretinoin — shown in clinical studies of photoaged skin¹
Softens fine lines and evens texture over timeTretinoin — results build over months, not days¹
GHK-Cu + estriol — a pairing you won’t find on a shelfGHK-Cu — supports repair signaling. Estriol — for skin in hormonal transition
One nightly step — pea-size, before bedRefills automatic; pause or cancel anytime
Get started →

¹ Findings from clinical studies of topical tretinoin in photoaged skin (see Sources & References). GHK-Cu and estriol are supporting actives; their effects in this formula have not been studied in trials. Compounded medications are not FDA-approved. Individual results vary.

A woman with luminous, healthy skin on the GLOW Protocol
Compare Your Options
I’m solving for
If this is you“Fine lines, dullness — everything at once”

Stella+

Flagship
For fine lines and firmness
GHK-CuEstriolTretinoinNiacinamide
$165/mo2-month plan · from $143
Fine lines & aging →
If this is you“Breakouts that track your cycle”

Flawless

For hormonal breakouts
AzelaicMetforminProgesteroneSpironolactone
$91/mo2-month plan · from $79
Hormonal breakouts →
If this is you“Dark spots that showed up and stayed”

Diamond Delux

For dark spots
HydroquinoneTretinoinTriamcinolone
$63/mo2-month plan · from $55
Dark spots →
If this is you“Pigment that has survived other creams”

Diamond Delux Plus

For stubborn pigment
HydroquinoneKojicTretinoinTriamcinolone
$63/mo2-month plan · from $55
Stubborn pigment →
If this is you“Rough texture, clogged pores, first fine lines”

Tretinoin TAAN

For texture and congestion
TretinoinAzelaicNiacinamide
$63/mo2-month plan · from $56
Texture & renewal →
If this is you“Uneven tone, redness, wanting the glow back”

Luminance

For uneven tone
AzelaicHydrocortisoneHydroquinoneKojic
$63/mo2-month plan · from $56
Tone & brightness →
Board-certified physicianslicensed in your state
Compounded by a US pharmacylicensed, audited, traceable
Free, discreet shippingincluded in your subscription
What You’ll Take

Your whole routine, compounded into one.

Six formulas, one nightly step — from Stella+'s four-active flagship to Flawless for PCOS-pattern skin. Your provider matches the formula and strength to your skin.

Why This Protocol

Prescription-strength, not drugstore.

Multiple prescription actives in one compounded cream — combinations you won't find on a shelf, cycled and supervised the way they should be.

About this protocol

Mechanism and dermatology context.

The medications

  • Stella+the four-active flagship cream
  • Flawlessthe hormonal-breakout formula
  • Diamond Delux & Plusthe pigment protocols, cycled
  • Tretinoin TAAN & Luminancerenewal and brightening

Inside the formulas

  • Tretinointhe renewal engine — texture, tone, fine lines
  • GHK-Cucopper peptide studied for collagen support
  • Niacinamide & Azelaic acidtone, redness, barrier support
  • Hydroquinone & Kojic acidpigment actives — enforced 12-week cycles
  • Estriol, Spironolactone & Metformin (topical)the hormone-aware layer

Creams ship at room temperature; use as directed by your pharmacy label. Physician-prescribed and dispensed by a licensed US pharmacy.

Your Skin Arc

Week 1-2

Skin may purge initially — part of the adjustment period as your routine begins.

Month 1

Texture begins smoothing. Skin feels different to the touch.

Month 3

In published ingredient studies, texture and tone improvements continued over time.¹

Month 6+

Ongoing renewal with consistent use. Individual results vary.

¹ Based on published studies of the individual ingredients — not clinical trials of this compounded product. Results vary.

Your timeline to treatment

From personalized intake to ongoing support, we help you get — and stay — on track.

Start The GLOW Protocol in 5 simple steps

Answer a few questions about your skin, goals, and health history — all online, no in-person appointment needed.

Take your online intake on your phone

A US-licensed clinician reviews your intake, evaluates your skin concern, and signs your prescription.

A licensed clinician reviews your intake

Your Rx is compounded in a US-licensed 503A pharmacy, lab-tested, sealed, and shipped — never sitting on a shelf.

US-licensed 503A pharmacy compounds your Rx

Your shipment arrives at your door — your compounded cream packaged with step-by-step usage guidance, ready to start that evening.

Your shipment arrives at your door

Ongoing care from our medical team — message your provider any time, with quick reviews and dose adjustments when needed.

Ongoing care from your provider

Peer-reviewed research and regulatory documents our medical team consults when evaluating intake for this protocol.

FDA / DailyMed

Retin-A® (tretinoin) prescribing information

Official FDA prescribing information for tretinoin (Retin-A), including indications, mechanism of action, dosing, contraindications (including pregnancy), and adverse reactions for topical retinoid therapy.

View source

FDA / DailyMed

Tri-Luma® (fluocinolone/hydroquinone/tretinoin) prescribing information

FDA prescribing information for the Tri-Luma combination formulation, establishing clinical reference data for hydroquinone-based combination therapies in melasma and hyperpigmentation treatment.

View source

Clinical Interventions in Aging (PubMed Central)

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Peer-reviewed review of the clinical evidence for topical retinoids in photoaged skin, including mechanisms of collagen induction, epidermal turnover, and outcomes across dose strengths.
Mukherjee S, Date A, Patravale V, et al. — Clinical Interventions in Aging 2006;1(4):327-348

View source

Journal of Dermatological Treatment

A double-blind, comparative, placebo-controlled study of 4% hydroquinone as a depigmenting agent in melasma

Randomised, double-blind, placebo-controlled trial of 4% hydroquinone in melasma, reporting depigmenting efficacy and tolerability.
Ennes SBP, Paschoalick RC, Mota de Avelar Alchorne M — Journal of Dermatological Treatment 2000;11(3):173-179

View source

Retin-A® and Tri-Luma® are registered trademarks of their respective owners. Nuvari is not affiliated with or endorsed by them.

Medical notice. The GLOW Protocol is a physician-prescribed compounded medication dispensed only after clinical evaluation of your skin type and concerns. Tretinoin is contraindicated in pregnancy. Hydroquinone should be used for limited durations as directed. Both formulations increase photosensitivity — daily sunscreen is mandatory. May cause dryness, peeling, redness, or initial breakouts during the adjustment period. Statements on this site have not been evaluated by the FDA.

Related reading

Background from the Nuvari journal on prescription skincare.

Rx vs OTC

Prescription skincare vs over-the-counter: what actually differs
Safety

Are compounded medications safe? How 503A pharmacies are regulated
Longevity

Where skin sits in a longevity protocol for men in their 30s
Pairs With

What Glow stacks with.

The protocols our providers most often add alongside this one.

Hair Loss · Restoration

Crown

Keep what's yours.
→
Peptide Therapy · Anti-Aging

Rewind

Support your body's natural renewal.
→
Sexual Health

Desire

Confidence when it counts.
→
Begin the GLOW →