Asleep sooner.
Awake better.

Sleep Support: Ramelteon & Trazodone

Built to help you fall asleep faster, stay asleep, and wake up clear.

Find my match

Non-habit-forming option

Ramelteonyour body’s own sleep signal

Magnesium L-threonatethe form that reaches the brain

SleepE Chewable

A man asleep on his side on pale blue linen as soft pre-dawn light moves across the bedding

Your clock, keptWORKS WITH YOUR BODY, NOT OVER IT

For harder nights An unmade bed in pale blue linen beside a switched-off bedside lamp in early morning light

Doxylaminehelps you drift off

Trazodonehelps you stay asleep

Melatoninsets your sleep rhythm

Knockout Tablet

One For Most Nights. One For The Harder Ones.

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

3, 6, and 12-month plans at checkout — save up to 20% · Cancel anytime · Knockout bills month to month only

Compounded medications are not FDA-approved.

RXSTART HEREMen & women

SleepE

Ramelteon Nightly chewable · 30 min before bed The gentler pick — helps you drift off, non-habit-forming. $79/moplans from $71 SleepE

Ramelteon Get started Important Safety Information

RXMONTHLY ONLYMen & women

Knockout

Doxylamine · Trazodone · Melatonin Nightly tablet · 30 min before bed The stronger pick — a 3-in-1 blend for staying asleep. $109/momonthly only — no autoship Knockout

Doxylamine · Trazodone · Melatonin Get started Important Safety Information

Every good day starts the night before.

Start the DRIFT

10:30 PMOne chewable, lights low

By 11Asleep on your own clock¹

3 AMFewer middle-of-the-night battles¹

6:30 AMUp without the fog¹

¹ Findings from clinical studies of the medications used in DRIFT formulas in specific study populations. Nuvari prescribes compounded formulations dispensed by licensed US pharmacies. Compounded medications are not FDA-approved. Individual results vary.

Compare Your Options

Which night are you having?

Most nights: SleepE

Helps you fall asleep naturally — and it’s not habit-forming.

Works with your body’s own sleep signal
Not habit-forming, not a controlled drug
Stronger than store-bought melatonin

The harder nights: Knockout

For nights that need more — three sleep helpers in one tablet.

Doxylamine, trazodone and melatonin in one
Monthly only — a provider checks in before each refill
No autoship, no discounts — on purpose, for safety

See both options and pricing ↑

Board-certified physicianslicensed in your state

Compounded by a US pharmacylicensed, audited, traceable

Free, discreet shippingincluded in your subscription

What You’ll Take

One dose before bed.

SleepE for most nights — non-habit-forming ramelteon with magnesium L-threonate, chewed 30 minutes before bed. Knockout for the harder ones, dispensed one month at a time with a provider reviewing every refill.

Why This Protocol

Sleep support without the dependence conversation.

Built around SleepE, our non-habit-forming flagship — with Knockout provider-gated for the nights that need more. Benzodiazepines are never prescribed.

About this protocol

Clinical context our providers use when matching the right sleep agent to your specific insomnia type.

The medications

SleepEthe nightly chewable for most nights
Knockoutthe three-active tablet for the harder ones, monthly-only

Inside the formulas

Ramelteonworks through your natural melatonin receptors — non-habit-forming
Magnesium L-Threonatemineral support co-formulated in SleepE
Doxylamineestablished sedating antihistamine
Trazodoneprescription support, used off-label for sleep at low dose
Melatoninthe familiar signal, in a measured dose

Both ship at room temperature. Knockout is provider-reviewed at every refill by design. Physician-prescribed and dispensed by a licensed US pharmacy.

How Drift Works

Intake reviewed

A US-licensed provider reviews your intake and determines whether treatment is appropriate for you.

Your option, matched

Your provider matches you to SleepE — the non-habit-forming flagship — or, where appropriate, Knockout for the harder nights.

Take as directed

Once nightly, exactly as directed by your provider — typically about 30 minutes before bed.

Refills & follow-up

Refills and follow-up run through your provider and your patient portal.

Sleep medications differ in how and when they act, and published findings describe study populations rather than any one person — individual results vary.

Your timeline to treatment

From personalized intake to ongoing support, we help you get — and stay — on track.

Start The DRIFT Protocol in 5 simple steps

Answer a few questions about your sleep patterns, health history, and current medications — all online, no in-person appointment needed. You'll find out if you're eligible within 24 hours.

A US-licensed clinician reviews your intake, identifies your insomnia type, and prescribes the single most appropriate medication — typically within 24 hours.

A licensed clinician reviews your intake

Your Rx is compounded in a US-licensed 503A pharmacy under USP <795>/<797> standards, lab-tested, sealed, and shipped — never sitting on a shelf.

US-licensed 503A pharmacy compounds your Rx

Your shipment arrives at your door — room-temperature, ready to go. Take once daily as directed by your provider, typically 30 minutes before bedtime.

Ongoing care from our medical team — message your provider any time, with quick reviews and dose adjustments when needed.

Sources & References

▾

Peer-reviewed research and regulatory documents our medical team consults when evaluating intake for this protocol.

FDA / DailyMed

Rozerem® (ramelteon) Prescribing Information

FDA-approved prescribing information for ramelteon — the melatonin receptor agonist used for sleep-onset insomnia — covering indications, pharmacology, dosing, and safety.
2023

View source

American Academy of Sleep Medicine

Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults

AASM evidence-based guideline recommending specific pharmacologic agents based on insomnia subtype — sleep onset, sleep maintenance, or combined — with strength-of-evidence ratings for each agent.
Sateia MJ et al. — Journal of Clinical Sleep Medicine, 2017

View source

Annals of Internal Medicine

Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the ACP

American College of Physicians guideline on chronic insomnia management, reviewing pharmacologic and behavioral approaches and informing prescribing decisions for non-habit-forming sleep agents.
Qaseem A et al. — 2016

View source

Rozerem® is a registered trademark of its owner. Nuvari is not affiliated with or endorsed by the trademark owner.

Medical notice. The DRIFT Protocol is a physician-prescribed medication dispensed only after clinical evaluation of your sleep pattern and medical history. May cause next-day drowsiness, dizziness, or dry mouth depending on the agent selected. Do not operate heavy machinery until you know how your medication affects you. Not appropriate for patients with severe hepatic impairment or untreated sleep apnea. Statements on this site have not been evaluated by the FDA.

Pairs With

What Drift stacks with.

The protocols our providers most often add alongside this one.

Peptide Therapy · Anti-Aging

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Asleep sooner.
Awake better.

Sleep Support: Ramelteon & Trazodone