Hormone Optimization · Men's Health

The APEX Protocol

Enclomiphene capsule — signals your body to make more of its own testosterone
One a day. No needles, no patches, no fertility shutdown
Room-temperature, discreet shipping — your provider sets the dose

Once daily oral capsule · Room-temperature shipment

Start intake

From $149/month · cancel anytime

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

Important safety information

Oral testosterone — full testosterone replacement, no needles
Daily dose · labs and provider follow-ups included
Replaces your own testosterone — not for those preserving fertility

Daily oral dose · Room-temperature shipment

Start intake

From $149/month · cancel anytime

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

Important safety information

Testosterone cypionate — clinical-grade full replacement
Weekly injection · labs and provider follow-ups included
Replaces your own testosterone — not for those preserving fertility

Weekly injection, subQ or IM · Cold-chain shipment

Start intake

From $149/month · cancel anytime

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

Important safety information

What It Is

Two paths to optimize your testosterone.

Boost your own — enclomiphene signals your body to make more of its own testosterone
Or replace it — clinical-grade testosterone, oral or injectable
Supports lean muscle, energy, and drive
Provider-matched to your labs and your goals, shipped to your door

Featured Image images/apex-hero.png

How it works

Boost it, or replace it — your call.

Apex offers two approaches. Enclomiphene signals your hypothalamic-pituitary axis to raise your own testosterone — taken orally, it keeps your natural production and fertility intact. Testosterone replacement instead supplies testosterone directly — a fuller effect, available oral or by weekly injection, with regular lab monitoring.

Which path fits depends on your goals: preserving fertility points toward enclomiphene; maximum replacement points toward testosterone. Your provider reviews your labs and history and recommends accordingly — dose decisions are based on your numbers, not a default template.

Apex Protocol · Enclomiphene or testosterone

Board-certified physicianslicensed in your state

Compounded by a US pharmacylicensed, audited, traceable

Free, discreet shippingincluded in your subscription

What You'll Take

One decision per month.

Your provider builds the protocol; you take one action a day. Refills are automatic, dose adjustments happen in-app, and you can pause or cancel any time.

Why This Protocol

Your testosterone, your way.

Boost your own with enclomiphene, or replace it with clinical-grade testosterone — your provider matches the approach to your labs and goals.

About this protocol

Technical and clinical context our providers use when evaluating intake for hormone-optimization therapy.

Boost or replace?

Boost — enclomiphene (a SERM) signals your pituitary to raise LH/FSH, so your body makes more of its own testosterone. Oral, and it keeps fertility on the table.
Replace — testosterone supplies it directly for a fuller effect, available as an oral dose or a weekly injection.
Your provider matches the approach to your labs, your goals, and whether fertility matters to you.
Labs at baseline; your provider rechecks around week 12 — and monitors testosterone therapy on an ongoing basis.
Both are physician-prescribed and dispensed by a licensed US pharmacy.

Storage & handling

Oral doses (enclomiphene, oral testosterone) store at controlled room temperature (68–77°F / 20–25°C); injectable testosterone ships cold-chain and is refrigerated.
Keep in original packaging away from moisture and direct sunlight.
Oral doses are taken daily; injectable testosterone is a weekly injection — follow your provider's instructions.
Compounded in a licensed US 503A pharmacy under USP <795>/<797> standards.
Testosterone is a Schedule III controlled medication; enclomiphene is not controlled.

Your Optimization Arc

A general arc — timelines vary by approach (boost vs. replacement) and by individual. Your provider sets expectations for your specific protocol. Individual results vary.

Week 1-2

Your body begins responding — on the boost path, LH and FSH start to rise; with replacement, testosterone climbs sooner.

Month 1

Testosterone levels begin climbing. Energy and mood improvements may start.

Month 2-3

T levels stabilize at your new baseline. Many notice changes in strength and drive — individual results vary.

Month 6+

Ongoing optimization. Your provider adjusts dosing based on lab results.

Your timeline to treatment

From personalized intake to ongoing support, we help you get — and stay — on track.

Start The APEX Protocol in 5 simple steps

Answer a few questions about your health, goals, and history — all online, no in-person appointment needed. No blood draw required to start. You'll find out if you're eligible within 24 hours.

A US-licensed clinician reviews your intake, follows up on anything that needs clarification, and signs your prescription — typically within 24 hours.

A licensed clinician reviews your intake

Your Rx is compounded in a US-licensed 503A pharmacy under USP <795>/<797> standards, lab-tested, sealed, and shipped — never sitting on a shelf.

US-licensed 503A pharmacy compounds your Rx

Your shipment lands at your door — oral doses at room temperature, injectable testosterone cold-packed with everything you need. Take or inject exactly as directed by your provider.

Ongoing care from our medical team — quick re-checks, dose adjustments when needed, and 24/7 access to your provider whenever a question comes up.

Sources & References

▾

Peer-reviewed research and regulatory documents our medical team consults when evaluating intake for this protocol.

FDA / DailyMed

Clomid (clomiphene citrate) Prescribing Information

FDA-approved label for clomiphene citrate — the parent compound of enclomiphene — defining indications, dosing, pharmacology, and safety profile.
2023

View source

Journal of Clinical Endocrinology & Metabolism

Enclomiphene citrate stimulates testosterone while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone

Phase II RCT demonstrating enclomiphene raises serum testosterone comparably to topical testosterone while preserving sperm counts, unlike TRT which suppresses spermatogenesis.
Kim ED et al. — 2016

View source

Fertility and Sterility

Clomiphene citrate and enclomiphene for the treatment of hypogonadal androgen deficiency

Review of mechanisms and clinical data for SERM-based testosterone stimulation via the HPG axis, with focus on fertility preservation compared to exogenous testosterone.
Hill S et al. — Expert Opinion on Investigational Drugs 2009

View source

American Urological Association

Evaluation and Management of Testosterone Deficiency: AUA Guideline

AUA's multidisciplinary clinical guideline on diagnosing and treating testosterone deficiency, including discussion of alternative agents such as SERMs for men wishing to preserve fertility.
Mulhall JP et al. — 2018

View source

Endocrine Society

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline

Evidence-based recommendations for diagnosing hypogonadism and initiating therapy, including guidance on fertility-preserving options for men with secondary hypogonadism.
Bhasin S et al. — Journal of Clinical Endocrinology & Metabolism 2018

View source

Medical notice. The APEX Protocol is physician-prescribed and dispensed only after a licensed clinician's review of your intake and clinical evaluation. Enclomiphene is not appropriate for men with primary hypogonadism, liver disease, or a history of venous thromboembolism, and may cause visual disturbances, mood changes, or headache. Testosterone (a Schedule III controlled medication) carries distinct risks — it can raise red-blood-cell count (hematocrit/polycythemia) and is associated with blood clots (DVT/PE) and cardiovascular events, requires ongoing lab monitoring, and is not appropriate for men with prostate or breast cancer. Discuss the risks of each option with your provider, and review the Important safety information for enclomiphene and testosterone. Compounded medications are not FDA-approved; statements on this site have not been evaluated by the FDA.

Pairs With

What Apex stacks with.

The protocols our providers most often add alongside this one.

Hormone Replacement · TRT

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The APEX Protocol

Two paths to optimize your testosterone.

Boost it, or replace it — your call.

One decision per month.

Your testosterone, your way.

About this protocol

Your timeline to treatment

Sources & References

Clomid (clomiphene citrate) Prescribing Information

Enclomiphene citrate stimulates testosterone while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone

Clomiphene citrate and enclomiphene for the treatment of hypogonadal androgen deficiency

Evaluation and Management of Testosterone Deficiency: AUA Guideline

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline

What Apex stacks with.

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