Hormone Optimization · Men's Health

The APEX Protocol

Enclomiphene + Tirzepatide · Combo Enclomiphene · Standalone

Boost your own testosterone and support metabolism
Daily oral capsule + low-dose weekly SubQ
TRT alternative that also helps with weight

Daily capsule + weekly SubQ · Cold-pack shipment

Choose your tier

Standard

$99/mo · 12.5 + 2.5 mg

Full

$129/mo · 25 + 5 mg

$99 / month

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

Important safety information

One capsule daily. No needles, no patches, no compounded creams.
Tells your body to produce more of its own testosterone — without suppressing the reproductive axis.
Discreet shipping, room-temperature storage. No cold chain, no clinic visits.

Once daily oral capsule · Room-temperature, discreet shipment

Choose your starting dose

12.5 MG

$199/mo

25 MG

$229/mo

50 MG

$259/mo

$199 / month

$597 billed every 12 weeks

Prescription only Free shipping Provider review in 24h US-licensed pharmacy

Important safety information

What It Is

Reclaim your own testosterone — without shutting your body down.

Signals your body to produce more of its own testosterone
One daily capsule — no needles, no injections
Supports lean muscle, energy, and drive
Convenient — shipped directly to your door

Featured Image images/apex-hero.png

How it works

How Apex actually works.

Apex works by signaling the hypothalamic-pituitary axis to increase gonadotropin output — your body responds by producing more of its own testosterone. No injections. No suppression of natural production. One capsule a day, and the axis stays intact.

Studies of enclomiphene in men with secondary hypogonadism have demonstrated meaningful increases in total testosterone while preserving sperm parameters. Your provider monitors labs throughout — dose decisions are based on your numbers, not a default template.

Apex Protocol · Enclomiphene citrate

Board-certified physicianslicensed in your state

Compounded by a US pharmacylicensed, audited, traceable

Free, discreet shippingincluded in your subscription

What You'll Take

One decision per month.

Your provider builds the protocol; you take one action a day. Refills are automatic, dose adjustments happen in-app, and you can pause or cancel any time.

Why This Protocol

Your body's own testosterone.

Enclomiphene signals your body to produce more T naturally — no injections, no shutdown, no fertility risk.

About this protocol

Technical and clinical context our providers use when evaluating intake for hormone-optimization therapy.

What is enclomiphene?

Your body restarts its own testosterone production — instead of getting replaced by it (SERM that raises LH/FSH at the pituitary)
Keeps fertility on the table — TRT usually takes it off
One capsule a day. No needles. No gels.
Labs at baseline. Your provider rechecks around week 12.
For men with low T who don't want to be on injections for life

Storage & handling

Store at controlled room temperature (68–77°F / 20–25°C).
Keep in original packaging away from moisture and direct sunlight.
Take once daily with or without food, as directed by your provider.
Compounded in a licensed US 503A pharmacy under cGMP standards.
Not a controlled substance — no special storage requirements.

Your Optimization Arc

Week 1-2

Your body begins responding to enclomiphene. LH and FSH levels start to rise.

Month 1

Testosterone levels begin climbing. Energy and mood improvements may start.

Month 2-3

T levels stabilize at your new baseline. Strength and drive feel noticeably different.

Month 6+

Ongoing optimization. Your provider adjusts dosing based on lab results.

Your timeline to treatment

From personalized intake to ongoing support, we help you get — and stay — on track.

Start The APEX Protocol in 5 simple steps

Answer a few questions about your health, goals, and history — all online, no in-person appointment needed. No blood draw required to start. You'll find out if you're eligible within 24 hours.

A US-licensed clinician reviews your intake, follows up on anything that needs clarification, and signs your prescription — typically within 24 hours.

A licensed clinician reviews your intake

Your Rx is compounded in a US-licensed 503A pharmacy under cGMP standards, lab-tested, sealed, and shipped — never sitting on a shelf.

US-licensed 503A pharmacy compounds your Rx

Your shipment lands at your door — room-temperature, ready to go. Oral capsule — no injections, no needles. Just take it once daily as directed by your provider.

Ongoing care from our medical team — quick re-checks, dose adjustments when needed, and 24/7 access to your provider whenever a question comes up.

Sources & References

▾

Peer-reviewed research and regulatory documents our medical team consults when evaluating intake for this protocol.

FDA / DailyMed

Clomid (clomiphene citrate) Prescribing Information

FDA-approved label for clomiphene citrate — the parent compound of enclomiphene — defining indications, dosing, pharmacology, and safety profile.
2023

View source

Journal of Clinical Endocrinology & Metabolism

Enclomiphene citrate stimulates testosterone while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone

Phase II RCT demonstrating enclomiphene raises serum testosterone comparably to topical testosterone while preserving sperm counts, unlike TRT which suppresses spermatogenesis.
Kim ED et al. — 2016

View source

Fertility and Sterility

Clomiphene citrate and enclomiphene for the treatment of hypogonadal androgen deficiency

Review of mechanisms and clinical data for SERM-based testosterone stimulation via the HPG axis, with focus on fertility preservation compared to exogenous testosterone.
Hill S et al. — Expert Opinion on Investigational Drugs 2009

View source

American Urological Association

Evaluation and Management of Testosterone Deficiency: AUA Guideline

AUA's multidisciplinary clinical guideline on diagnosing and treating testosterone deficiency, including discussion of alternative agents such as SERMs for men wishing to preserve fertility.
Mulhall JP et al. — 2018

View source

Endocrine Society

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline

Evidence-based recommendations for diagnosing hypogonadism and initiating therapy, including guidance on fertility-preserving options for men with secondary hypogonadism.
Bhasin S et al. — Journal of Clinical Endocrinology & Metabolism 2018

View source

Medical notice. The APEX Protocol is a physician-prescribed compounded medication dispensed only after a licensed clinician's review of your intake and clinical evaluation. Not appropriate for men with primary hypogonadism, liver disease, or a history of venous thromboembolism. Enclomiphene may cause visual disturbances, mood changes, or headache — discuss with your provider. Statements on this site have not been evaluated by the FDA.

Pairs With

What Apex stacks with.

The protocols our providers most often add alongside this one.

Hormone Replacement · TRT

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The APEX Protocol

Reclaim your own testosterone — without shutting your body down.

How Apex actually works.

One decision per month.

Your body's own testosterone.

About this protocol

Your timeline to treatment

Sources & References

Clomid (clomiphene citrate) Prescribing Information

Enclomiphene citrate stimulates testosterone while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone

Clomiphene citrate and enclomiphene for the treatment of hypogonadal androgen deficiency

Evaluation and Management of Testosterone Deficiency: AUA Guideline

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline

What Apex stacks with.

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